A single misstep can cascade into a catastrophic failure, as DrugHub’s saga so vividly illustrates. DrugHub’s origins trace back to the remnants of White House Market and its eventual merger with Supermarket. The platform’s creators, likely seasoned veterans of the darknet ecosystem, should have known better than to leave such glaring vulnerabilities. Yet, these oversights suggest a departure from the meticulous operational security (OPSEC) practices that once defined successful darknet marketplaces. Our modification of the semantic comparison model will generate comparable word embeddings for opioid jargon words in legitimate documents (ie, benign corpora embedding) and in underground corpora (ie, underground corpora embedding). Specifically, our modification used a series of opioid keywords collected to generate their benign corpora embeddings and then searched for words whose underground corpora embeddings were close to the opioid keywords’ benign corpora embeddings.
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We will post updates regarding extended downtime, security incidents, or migration notices. It is a priority for CBC to create products that are accessible to all in Canada including people with visual, hearing, motor and cognitive challenges. Jones has repeatedly rejected the suggestion that drug users could die as a result of a shift toward an abstinence-based treatment model. The Ontario government said Thursday nine existing supervised drug consumption sites throughout the province have been approved to transition into new “homelessness and addiction recovery hubs.” The life sciences industry continues to pour manufacturing investments into the state. GSK announced plans in September to build an additional new biologics flex factory at Upper Merion focused on medicines for respiratory disease and cancer, with construction planned to start this year.
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This is the first study to measure and characterize opioid trading in anonymous online marketplaces and forums. From our measurement, we concluded that anonymous online marketplaces and forums provided easy-access platforms for global opioid supply. This paper seeks to complement current studies widening the understanding of opioid supply chains in underground marketplaces using comprehensive, large-scale, longitudinal anonymous marketplace and forum data. To this end, we propose a series of techniques to collect data; identify opioid jargon terms used in the anonymous marketplaces and forums; and profile the opioid commodities, suppliers, and transactions. Specifically, we first conducted a whole-site crawl of anonymous online marketplaces and forums to solicit data.
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Our goal here was to identify anonymous forum posts with the topics of opioid commodity promotion (eg, listing promotion) and review (eg, report fake opioid vendors). We then analyzed these forum posts to profile underground opioid trading behaviors. To collect the listing information of 5 anonymous online marketplaces (ie, Apollon, Avaris, Darkbay, Empire, and The Versus Project), we conducted a whole-site crawl. The crawler was implemented in Python and used the Selenium module to launch browsers and to send crawling requests [24]. To avoid blocking from the marketplace, we provided as an input to the scraper a session cookie that we obtained by manually logging into the marketplace and solving a Completely Automated Public Turing test to tell Computers and Humans Apart (CAPTCHA). However, some sites, namely, the Empire Market, forced users to log out when the life span of the session cookie was expired.
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Longevity biotech Juvenescence today announced the first close of its Series B-1 financing round, securing $76 million to support the continued development of its AI-driven clinical pipeline focused on age-related diseases. The round was led by M42, a tech-enabled healthcare company headquartered in Abu Dhabi, with additional participation from existing investors. The full close of the financing round is expected in the third quarter of this year, with the company reportedly aiming to raise more than $150 million in total. Violations of platform rules can result in a fine, account suspension andfund forfeiture. We maintain a zero-tolerance policy for prohibited items toensure marketplace safety and for the health of the darknet ecosystem.
Ontario supervised drug consumption sites set to close under new law will become treatment hubs
In total, we collected 248,359 listings from 10 anonymous online marketplaces and 1,138,961 traces (ie, threads of posts) from 6 underground forums. As observed in our data set, the top 3 marketplaces with the most opioid listings are Agora, Evolution, and Apollon. This section elaborates on the methodology used to identify opioid trading information in the anonymous market and forums. Specifically, we collected approximately 248,359 unique listings and 1,138,961 unique forum traces (ie, threads of posts) from 10 anonymous online marketplaces and 6 forums.
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The seized drugs include over 569 pounds of amphetamines, 95 pounds of cocaine, 95 pounds of MDMA and over 22 pounds of LSD and ecstasy pills, the agency said. Applications for the remaining 10 hubs are under review and will be announced in the coming weeks, the province said in the release, adding the goal is to have the facilities up and running by April 1. Hikma Pharmaceuticals USA broke ground in June on a pharmaceutical manufacturing and R&D facility in Columbus. The company also pledged $1 billion by 2030 to further expand its US manufacturing and R&D capabilities. Among them is Amgen, which in April announced a $900 million expansion of its Ohio manufacturing facility as part of a $1.4 billion investment plan it said has created 750 jobs. In addition, J&J kicked off 2026 by announcing plans to build a next-generation cell therapy manufacturing site in Pennsylvania.
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- Violations of platform rules can result in a fine, account suspension andfund forfeiture.
- Among them is Amgen, which in April announced a $900 million expansion of its Ohio manufacturing facility as part of a $1.4 billion investment plan it said has created 750 jobs.
- Welcome to Drughub Market, the premierdarknet platform crafted by the esteemed White House Market team, operatingsecurely for over 2 years.
- Note that we determined if 2 listings are identical by matching the same elements (ie, listing’s title and description information and the vendor’s name) in 2 listings.
- After that, an opioid buyer often leaves review comments under the product listing or discusses the purchasing experience in the forum (step 12).
- With a keen interest in the transfer of technology to market, he focuses primarily on the companies working on cutting-edge solutions to aging and age-related diseases.
The expanding pharmaceutical sector and international partnerships are facilitating access to innovative therapies. Challenges such as limited healthcare resources are being addressed through policy reforms and investments in diagnostic facilities. The focus on expanding treatment options and clinical research is expected to accelerate market growth, making Pakistan an emerging hub for pancreatic and bile duct cancer therapeutics in the region.
Escrow Process
- The company also pledged $1 billion by 2030 to further expand its US manufacturing and R&D capabilities.
- Hence, every word has 2 vectors, each describing the word’s relations with other words in one corpus.
- Revolutionizes pre-clinical and clinical drug development through its cutting-edge organoid technology, enhancing its accuracy and efficiency.
- To better understand the potential bundling relationship of opioid suppliers across different marketplaces, we calculated the Jaccard similarity coefficient between the suppliers in different marketplaces (Figure 6).
- At Market Research Intellect, our mission is to bridge the gap between data and decision-making.
- Violations of platform rules can result in a fine, account suspension andfund forfeiture.
- Note that we determined if 2 listings are identical by matching the same elements (ie, listing’s title and description information and the vendor’s name) in 2 listings.
- In our study, we found that 23.78% (9896/41,614) listings and traces were identified with the help of 58 opioid jargons (Table 2).
- “Frost & Sullivan identifies HUB’s epithelial tissue-based technology as groundbreaking and innovative.
- It’s part of a bigger $1.2 billion investment in advanced manufacturing facilities, AI and advanced digital technologies that will also include new capabilities.
- As the healthcare system continues to evolve, Sri Lanka is positioning itself as a key player in regional cancer management, with an emphasis on innovative therapies and patient-centric care models.
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Become part of the #1 darknet marketplace trusted by over 500,000 users and 100k+ listings. Frost & Sullivan Best Practices Awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.
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Experienced vendors with 250+ successful sales on other established darknetmarketplaces can apply for instant approval on Drughub Market. Our verification process for the Drughub darknet includes thorough reputationchecks, transaction history reviews, and advanced security assessments. Join theDrughub dark web marketplace today tostart selling securely via our verified Drughub market onion links and official Drughub mirrors.
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We are a pan-Canadian collective of harm reductionists, drug policy activists, and people who use(d) drugs. Drug Hub features a unique mirror distribution system where each user receives personal mirror links. Unlike traditional marketplaces with shared backup mirrors, our system provides truly unique onion addresses for enhanced security and reliability. Last month, a social services agency in Toronto launched a legal challenge against the law limiting supervise consumption sites, arguing it infringes on the Charter rights to life, liberty and security of person.
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- When interpreted by professionals, our initial results demonstrate useful findings and may be used downstream by law enforcement and public policy makers for impactful structural interventions to the opioid crisis.
- In the highly competitive and precarious world of darknet marketplaces, such decisions can be the difference between thriving and imploding.
- To combat DDOS attacks and phishing sites, DrugHub requires users to obtain links through a rotating mirror site first.
- We observed that the marketplaces of Agora and Evolution shared 530 opioid listings from 290 unique supplier IDs.
- In DrugHub’s case, the risks were amplified by its server’s geographical location and its choice of hosting providers.
- Our verification process for the Drughub darknet includes thorough reputationchecks, transaction history reviews, and advanced security assessments.
- Challenges include supply chain disruptions, cost volatility, and regulatory compliance pressures.
- This is the only official marketplace URL—any other address claiming to be Drug Hub is a phishing attempt.
“We have heard loud and clear from families across Ontario that drug injection sites near schools and child-care centres are making our communities less safe,” Jones said in a statement, adding the hubs will improve access to mental health and addiction services. While the UAE’s hosting infrastructure offers certain advantages, it also brings the platform within the jurisdictional drug hub reach of international law enforcement. A bilateral treaty between the UAE and the United States allows for the extradition of individuals involved in criminal activities, making DrugHub’s choice of location a precarious gamble. For example, there might be varying types of heroin or fentanyl, but we could not subcategorize them due to the lack of precise ontology.
Durham Community Health Centre (Oshawa)
It’s part of a bigger $1.2 billion investment in advanced manufacturing facilities, AI and advanced digital technologies that will also include new capabilities. With Philadelphia a long-established pharma hotspot and Pittsburgh an emerging one, Pennsylvania’s life sciences sector employs 100,000 workers across nearly 3,100 companies that have secured more than 10,700 new life sciences patents over the past five years. Everything’s bigger in Texas, the saying goes, and that’s true of Eli Lilly’s plans to build a new $6.5 billion manufacturing facility in Houston, marking one of the state’s biggest life sciences investments.
HUB meticulously crafts its targeted marketing campaigns to highlight specific applications of organoid technology to accelerate and improve drug testing. The company’s proactive approach to using digital platforms for outreach has played a crucial role in demystifying complex scientific processes and showcasing the tangible benefits of organoids in drug discovery and development. This award recognizes HUB at the forefront of innovation and growth in the field of organoid technology, continuously improving its offerings to meet the dynamic needs of drug developers and providing state-of-the-arts solutions.
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Digital transformation increases efficiency, data-driven decision-making, and adoption of advanced solutions. Regulations influence product standards, sustainability compliance, and market entry strategies. Challenges include supply chain disruptions, cost volatility, and regulatory compliance pressures. Key trends include automation, digital integration, smart systems, and innovation-led product development. Besides these books, Kuzmarov has published hundreds of articles and contributed to numerous edited volumes, including one in the prestigious Oxford History of Counterinsurgency .
International collaborations and investments in healthcare technology are fostering innovation and market development. The focus remains on enhancing treatment accessibility and integrating advanced therapies, positioning Bangladesh as an emerging market for pancreatic and bile duct cancer management in South Asia. The opioid buyer (client) will also access the anonymous online market and create an account in each anonymous marketplace before they can find the listings of opioids (step 4). After perusing the items available on the anonymous online market (step 5), the buyer will add opioids to their shopping cart (step 6). When the buyer wants to check out and make a purchase using cryptocurrency (eg, Bitcoin), if the trader accepts payment through an anonymous online marketplace as an escrow, the buyer will place the listed amount of cryptocurrency in escrow (step 7). Otherwise, the buyer will pay the trader directly using cryptocurrency or any other payment method accepted by the trader (step 9) [7].
This is because the same user could have different IDs, and the same ID in different marketplaces can point to different users. Owing to the anonymity of the underground marketplaces and forums, there exists no ground truth to link users with their IDs. The global market for pancreatic and bile duct cancer therapeutics is experiencing significant growth driven by advancements in targeted therapies, increasing prevalence of these cancers, and expanding research initiatives. The rising adoption of personalized medicine and innovative drug delivery systems further contribute to market expansion.
We found evidence through extensive analyses of the anonymous online market of pervasive supply, which fuels the international opioid epidemic. Nontraditional methods, as presented here by studying the online supply chain, present a novel approach for governmental and other large-scale solutions. When interpreted by professionals, our initial results demonstrate useful findings and may be used downstream by law enforcement and public policy makers for impactful structural interventions to the opioid crisis. Although a large body of current research is focused on pathways for treatment of opioid use disorder and analyzing deaths per treatment capacity of substance use providers, these research areas are limited to the demand side of the opioid epidemic [40,41]. We believe that the findings and pattern analyses presented here, which place concentration on the supply side, might suggest a new direction to focus and will serve as a useful complement to current research conducted within the domain of addiction medicine.
We output the top 100 proper nouns in the underground corpora in our implementation, whose embeddings showed the closest cosine distance to the known opioid keywords. DrugHub Market is the top darknet marketplace from the team behind White House Market. Never access Drug Hub or any darknet marketplace without proper security precautions. Always use Tor Browser with security level set to “Safest.” Encrypt all sensitive communications with PGP. 🚨 DrugHub is the leading darknet marketplace for verifiedvendors, over 100,000+ listings, over 500,000 active users, and more than 4,000 trusted vendors. Launched in August 2023 bythe legendary team behind White House Market, DrugHub has quickly become the topdarknet market globally.
Welcome to Drughub Market, the premierdarknet platform crafted by the esteemed White House Market team, operatingsecurely for over 2 years. As the number one market today, we pride ourselves onour advanced escrow protection androbust security systems, ensuring every transaction remains safe and secure. Monero (XMR) is the sole payment method,providing maximum privacy and anonymity for users navigating the dark web.Launched two years ago, Drughub Market has set the standard for reliability andsecurity. Find our official onion link and verified mirror here to access ourmarketplace for an unparalleled, private browsing experience. Note that we should not overestimate the number of suppliers and buyers given the number of IDs found in this research, but we regarded it as the upper-bounded number of the opioid suppliers and buyers.
Public documentation revealed the use of port 5222, a choice that, while functional, is fraught with risks. This port, coupled with the use of both Tor and clearnet mirrors, significantly increased the attack surface for adversaries. The possibility of intercepting user data became more than a theoretical risk—it was a plausible scenario that could compromise both buyers and vendors alike. Note that data for 2020 only included data from January to March; price per gram is in US $.
The results show that vendors’ trustworthiness is a better predictor of vendor selection than product diversity or affordability. Considering social media data (eg, Twitter and Instagram), Nasralah et al [14] proposed a text mining framework to collect opioid data from social media and analyzed the most discussed topics to profile the opioid epidemic and crisis. Mackey et al [13] collected tweets related to the opioid topic to identify illicit online pharmacies and study the illegal sale of opioids in online marketing. Cherian et al [12] gathered codeine misuse data from Instagram posts to understand how misuse is happening and its misused form. However, to the best of our knowledge, no large-scale study, which may cross multiple anonymous marketplaces and is cross-sectional, has been conducted to profile the opioid supply chain and unveil characteristics of opioid suppliers, commodities, and transactions. To the best of our knowledge, a comprehensive overview of the opioid supply chain in the anonymous online marketplaces and forums, as well as a measurement study of trading activities, is still an open research challenge.
A total of 248,359 listings from 10 anonymous online marketplaces and 1,138,961 traces (ie, threads of posts) from 6 underground forums were collected. Recent years have witnessed the trend of studying opioid use disorders using anonymous marketplaces and forums data [5,8,10] and public social media data (eg, Twitter and Instagram) [11-14]. Gilbert et al [15] described changes in the conceptualizations, techniques, and structures of opioid supply chains and illustrated the diversity of transactions beyond the traditionally linear conceptualizations of cartel-based distribution models. Quintana et al [16] and Fernando et al [17] presented the results of the international drug testing service for opioid commodities from the anonymous marketplaces and showed that most opioid substances contained the advertised ingredient and most samples were of high purity. Dasgupta et al [18] collected opioid listings on Silk Road to analyze the prices of diverted prescription opioids. Duxbury et al [6] evaluated the role of trust in online drug markets by applying exponential random graph modelling to underground marketplace transactions.
Note that the escrow mechanism is widely deployed in the anonymous online market because it helps to build trust and resolve disputes between sellers and buyers. When the purchase is made, the opioid trader ships the purchased item to the buyer (step 10). Once the item is received, the buyer finalizes the purchase by notifying the anonymous online marketplace to release the funds held in escrow (step 11) [8,9]. After that, an opioid buyer often leaves review comments under the product listing or discusses the purchasing experience in the forum (step 12). The Vietnamese market for pancreatic and bile duct cancer drugs is projected to grow steadily over the next five years, driven by increasing healthcare investments and rising awareness about early diagnosis.
To better understand the potential bundling relationship of opioid suppliers across different marketplaces, we calculated the Jaccard similarity coefficient between the suppliers in different marketplaces (Figure 6). We found that 182 opioid supplier IDs appeared in both the marketplaces Evolution and Agora from January 2014 to July 2015. In particular, we observed that 84 opioid supplier IDs synchronized similar product listings in both marketplaces at the same time. This might be because the suppliers tend to promote their products across various marketplaces and to increase sales.